Professor Mark Little

Professor Mark Little
TitleProfessor Mark Little
Contact Details01 414 2353
Trinity Health Kidney Centre

Special Interests

Autoimmune kidney disease


Graduate of TCD 1993


Clinician Scientist with experience of international academic leadership in the field of autoimmune kidney disease. 

Professor Little runs a translational medicine research programme focused on investigation of pathogenesis and discovery of biomarkers of disease in glomerulonephritis. His principal research interest is in ANCA vasculitis, an autoimmune condition that causes multi-organ failure as a consequence of overwhelming necrotising inflammation affecting small blood vessels.

In this research the following questions are being addressed:
1. What biomarkers accurately track glomerular and extra-renal inflammation in ANCA associated vasculitis?
2. What molecular and cellular events prevent resolution of vasculitic injury after the initial insult?
3. What underpins the large variability in clinical phenotype observed in ANCA associated vasculitis?
4. How can we minimise the adverse events associated with existing immunosuppressive therapies?

To assist in answering these questions, an infrastructure has been set up that enables the collection of longitudinal clinical data in the form of a national registry and biobank, which is linked to a basic science laboratory. To find out more about Professor Little and his research click here


President of Ireland Young Researchers Award

Professional Memberships

Fellow of Trinity College Dublin
Fellow of the Royal College of Physicians
American Society of Nephrology
The Renal Association