Clinician Scientist with experience of international academic leadership in the field of autoimmune kidney disease.
Professor Little runs a translational medicine research programme focused on investigation of pathogenesis and discovery of biomarkers of disease in glomerulonephritis. His principal research interest is in ANCA vasculitis, an autoimmune condition that causes multi-organ failure as a consequence of overwhelming necrotising inflammation affecting small blood vessels.
In this research the following questions are being addressed:
1. What biomarkers accurately track glomerular and extra-renal inflammation in ANCA associated vasculitis?
2. What molecular and cellular events prevent resolution of vasculitic injury after the initial insult?
3. What underpins the large variability in clinical phenotype observed in ANCA associated vasculitis?
4. How can we minimise the adverse events associated with existing immunosuppressive therapies?
To assist in answering these questions, an infrastructure has been set up that enables the collection of longitudinal clinical data in the form of a national registry and biobank, which is linked to a basic science laboratory. To find out more about Professor Little and his research click here